Monday, November 30, 2015

Why did the narrator find Laura interesting?

In the book, the narrator found Laura interesting because her maternal instincts never seemed to wane despite having had eight children with seven different men. He marveled at Laura's sense of humor, her affection for her children, and her fortitude in the face of adversity. The narrator was also amused that Laura used colorful language with her children, but he noted that her love for her children was evident for all to see.


In due time, the narrator maintained that he was fascinated by the changes Laura went through during each of her pregnancies. On a cyclical basis, her body weathered the necessary biological changes and emerged unscathed from each experience.



I would notice her belly rising for months. Then, I would miss her for a short time. And the next time I saw her, she would be quite flat. And the leavening process would begin again in a few months. To me, this was one of the wonders of the world in which I lived, and I always observed Laura.



As a neighbor, Laura always found time for her young neighbor, the narrator. She gave him plums, mangoes, and sugar-cakes whenever she had some to share. Laura was also cheerful despite her straitened circumstances. The narrator also found Laura an interesting woman because she managed to attract many lovers despite being plump and being the unlucky possessor of "a face like the top of a motor-car battery." In all, the narrator found Laura interesting because she never lost her zest for life despite her difficult circumstances.

What is 2/2?

In mathematics, '/' represents division, and also uses the following symbol: `-:`


Now let's solve the question given: `2//2 = 1`


Any number divided by the same number, except for the number '0', will yield an answer of '1'. 


Let's look at several other examples: 


`5//5 =1`


`2000//2000 = 1`


`(-5)//(-5) = 1` 


Also when a negative number is divided by a negative answer the answer is still '1'


`(2/3)//(2/3) = 1`


Also when the same number as a fraction is divided by the same number as a fraction, the answer yield is also '1'


Speaking of fractions, the above question can also be written as a fraction as follows: `2/2`


When we calculate the fraction we get the same answer: 


`2/2 = 1`


The fraction line that differentiates the numerator and the denominator acts as a division line as well. 


SUMMARY: 


2/2 = 1

Consider the Treaty of Fort Laramie (1868): What were the issues of contention and where did communication fail?

The Treaty of Fort Laramie of 1868, which ended Red Cloud's War, ceded much of the western part of South Dakota, including the Black Hills, to the Lakota Sioux and Northern Cheyenne. The issues involved in the treaty were that the Black Hills were considered sacred to the Sioux, and they became part of the Great Sioux Reservation. Whites were not allowed to trespass on these lands.Hunting grounds were also granted to Native Americans in South Dakota, Wyoming, and Montana. The treaty also provided money to Native Americans who chose to farm, and it stipulated that children would attend English-language schools.


The communication between whites and the Sioux and Cheyenne broke down over time. In 1874, General Custer led miners into the Black Hills as part of an expedition, and eventually, gold was discovered in the area. The government could not keep miners out of the area, and the Sioux and Cheyenne did not want to return their lands to the United States government. A series of battles, referred to as the Black Hills War or Great Sioux War of 1876, followed. The most famous battle was the Battle of Little Bighorn, in which Custer's 7th Cavalry was wiped out by Native Americans in 1876. The U.S. government annexed the land in 1877, and the Sioux are still involved in a court battle with the U.S. government over the land. 

What is countertransference?



In countertransference, a mental health counselor or therapist develops emotions about a patient being treated. These emotions can be positive or negative. For example, the therapist may begin feeling loving or protective toward the patient, or the therapist might feel dislike or anger. Both types of feelings can create roadblocks to treatment. In all circumstances, it is unethical for therapists to act on countertransference. However, a good therapist will use his or her feelings to learn more about the patient and create a better outcome to the therapy.


Countertransference is the opposite of
transference
, which involves the patient projecting, or transferring, his or her feelings onto the therapist. Transference is common during mental health treatment. Some experts believe that transference occurs naturally as the therapist and patient develop a relationship that is based on trust and confidence. Experts say transference is a sign that the patient is making good progress.




Overview

The term countertransference was originally coined by Sigmund Freud (1856 – 1939), an Austrian neurologist who famously developed
psychoanalysis
, a method of treating mental disorders that examines the interaction between the conscious and unconscious mind. Freud considered countertransference to be damaging, unhealthy, and undesirable for mental health practitioners.


Although modern experts agree with Freud that acting
on countertransference is undesirable and damaging, they also believe that countertransference can be a tool for therapists to better understand their patients. Two types of countertransference exist: subjective and objective.




Subjective Countertransference

Subjective countertransference involves feelings that are rooted in the therapist's own issues and have little to do with the patient. These feelings may arise as irritation or anger toward the patient. At times, however, the therapist might begin to feel an irrational level of love or caring toward the patient. Additionally, countertransference may also take the form of sexual desire.


Subjective countertransference involves feelings that have to do with the therapist as a person. They can point to unresolved issues that are awakened within the therapist through his or her work with the patient. Sometimes these feelings are related to people currently in the therapist's life; other times they point to unresolved problems from the past. Whatever the case, these feelings are distracting and the therapist may have a difficult time treating the patient.




Objective Countertransference

Objective countertransference also involves the therapist's emotions. However, in objective countertransference, the therapist feels what the patient feels, experiencing the patient's feelings toward him- or herself. The therapist may also experience the feelings of important individuals in the patient's life, such as original caregivers, significant others, siblings, and children. The types of feelings that arise in the therapist are based in the patient's personality and interpersonal strategies. For example, patients who rely on strategies of
repression
(protecting themselves from threatening thoughts by blocking them out) or
denial
(refusing to face unpleasant facts or realities) may bring these out in the therapy session. Similarly, patients who interact with others using stonewalling (refusing to cooperate) or clinging (emotionally or mentally holding on to others too tightly) strategies will likely bring these out in the therapist.


Because these feelings arise from the patient, they provide important clues that the therapist can use to better understand the patient and to direct treatment. Objective countertransference is now widely acknowledged as a powerful clinical tool.




Dealing with Countertransference

A therapist often feels a combination of subjective and objective countertransference when working with a patient. It is important for the therapist to know how to distinguish his or her own feelings from feelings that belong to the patient. One simple technique is for the therapist to pay attention to how long the feelings last. If an emotional state quickly ends once the session is over, the feelings are likely objective countertransference that come from the patient. If the therapist continues to feel the emotions for an extended period of time after the session, however, the feelings may be subjective in nature and should be addressed.


When a therapist becomes aware of subjective countertransference, he or she should deal with the feelings appropriately. Therapists are encouraged to distance themselves from their feelings. They might choose to talk about them with a trusted colleague or a supervising therapist to grow both personally and professionally. Sometimes, the wisest course of action is to transfer the client to another therapist.




Ethics Code

The American Psychological Association (APA) is a respected professional organization that works to advance knowledge about psychology to help individuals and society. Most mental health practitioners are members or associate members of the APA.


The APA helps its members to stay committed to the ideals of the profession by behaving in ethical (moral or just) means. The APA promotes appropriate ethical conduct through a variety of means, including its Ethical Principles of Psychologists and Code of Conduct, also known as the Ethics Code. The Ethics Code sets forth broad rules and specific guidelines designed to help mental health practitioners make ethical professional decisions. One of these rules is to avoid harming the client. When applied to the experience of countertransference, this means that therapists should never act on their feelings toward patients. They should never attempt to have sexual or romantic relationships with patients and instead should focus on giving the patient the best treatment possible.




Bibliography


"About APA." The American Psychological Association. American Psychological Association. 2015. Web. 22 Jan. 2015. http://www.apa.org/about/index.aspx



Cartwright, C. "Transference, Countertransference, and Reflective Practice in Cognitive Therapy." Clinical Psychologist, vol. 15, 112-120. 2011. Web. 22 Jan. 2015. http://www.researchgate.net/profile/Claire_Cartwright/publication/258312764_Transference_countertransference_and_reflective_practice_in_cognitive_therapyc_p_30_112..120/links/02e7e527c8bcf97ac8000000.pdf



Rathe, Elissa Lin, Ph.D. "Transference and Countertransference from a Modern Psychoanalytic Perspective." North American Association of Christians in Social Work. North American Association of Christians in Social Work. 1 Feb. 2008. Web. 20 Jan. 2015. http://www.nacsw.org/Publications/Proceedings2008/RatheETransference.pdf



"Sigmund Freud." Bio. A&E Television Networks, LLC. 2015. Web. 20 Jan. 2015. http://www.biography.com/people/sigmund-freud-9302400#video-gallery

Who did Montezuma rule?

Montezuma II was the Tlatoani of the city of Tenochtitlan (modern day Mexico City), the capital of the Aztec Empire (or the Triple Alliance). He reigned during the initial contact between Europeans and the indigenous peoples of Mesoamerica in 1519 when Hernan Cortes reached the New World. The people he ruled, the Aztecs, lived in the Valley of Mexico, and in the final stages of their history were ruled by three city-states.


Government


When Montezuma ruled, the Aztecs were organized into the Triple Alliance, a name referring to the union of three city-states (Tenochtitlan, Texcoco, and Tlacopan). Tenochtitlan was the dominant city, and its ruler (the Tlatoani) was effectively the leader of the entire empire. Other cities and peoples conquered by the Aztecs were allowed to live in relative freedom so long as they paid a tribute to the conquering government. Below the city level, families were organized into clan-like units called calpullis, which owned and managed the land that family units lived on.


Language, Culture, and Religion


The Aztecs spoke a language called Nahuatl, which is still spoken today in Central Mexico. They were polytheistic, worshipping many gods, and their religion dealt predominantly with the attempt to keep nature in balance through understanding how humans and gods were connected. Human sacrifice was an important practice in Aztec religion, and those sacrificed were given over to the god Huitzilopochtli, patron of war and the sun, in his unending fight against darkness.


All Aztecs were required to undergo a formal education, regardless of the gender or social class of the student. There were two classes in Aztec culture, the pilli (nobility) and the macehualli (commoners). Within these two classes, there were further divisions of labor and roles.


Unfortunately, the Aztec Empire would see the beginning of its undoing during Montezuma's rule, ushering in an age of European colonization in Mesoamerica. 

Sunday, November 29, 2015

Did Charlie die at the end of Flowers for Algernon by Daniel Keyes?

Though Charlie Gordon does not physically die at the end of Flowers for Algernon by Daniel Keyes, it is suggested that he might because he has, after all, followed the fate of Algernon fairly closely up to this point. Charlie does realize his newfound intelligence is evaporating quickly, and that soon he will have even less of it than he did before the operation. For this reason, he checks himself into the Warren State Home, an institution for mentally disabled children and adults. Charlie does not want to be pitied by his former co-workers or by anyone else, so he decides that this is the best place for him to live out whatever time he has left. He does this in spite of the fact that when he visited there previously, the home with its overworked staff and affection-starved residents thoroughly depressed him. However, Charlie would rather be there than have the people he loved or befriended feel sorry for him.

Does nitrogen react with oxygen or petrol in car engines to form oxides of nitrogen?

Nitrogen reacts with oxygen to form nitrogen monoxide. Nitrogen monoxide is also sometimes called nitric oxide. The balanced reaction between nitrogen and oxygen is:


  `~N_2 + ~O_2 -gt ~2NO`


Nitrogen and oxygen are both diatomic elements. This means that they exist in nature as two atoms bonded together. `~N_2` , `~O_2` , and NO are all covalently bonded molecules and are gases at room temperature.


An oxide is a two-element compound with oxygen being one of the compounds. Other examples of oxides include: nitrous oxide (`~N_2O` ), carbon dioxide (`~CO_2` ), and calcium oxide (CaO).


Petrol is composed of hydrocarbons. A hydrocarbon is a compound composed of hydrogen and carbon atoms. The hydrocarbons in gasoline contain between 5 and 12 carbon atoms. Examples of other hydrocarbons include: methane (`~CH_4` ) and ethane (`~C_2H_6` ).

Friday, November 27, 2015

Is the pursuit of pleasure considered a sin in To Kill a Mockingbird?

In Harper Lee's To Kill a Mockingbird, there are only a few characters who believe that the pursuit of pleasure is a sin.

In Chapter 5, when Scout asks Miss Maudie if she thinks their neighbor, Arthur (Boo) Radley, is still alive and why he never leaves his house, Miss Maudie responds by explaining to Scout the religious beliefs of the Radley family. According to Miss Maudie, Arthur Radley's father was a "foot-washing Baptist." Miss Maudie further explains the following to Scout:



Foot-washers believe anything that's pleasure is a sin. Did you know some of 'em came out of the woods one Saturday and passed by this place and told me me and my flowers were going to hell? ... They thought I spent too much time in God's outdoors and not enough time inside the house reading the Bible. (Ch. 5)



Hence, based on Miss Maudie's explanations, we can deduce that one reason why Arthur Radley never leaves his home is because he has been taught to believe that anything he finds pleasure in doing, such as being outside, is a sin.

However, not many characters in the novel agree with the perspective of foot-washing Baptists. Aside from Miss Maudie taking pleasure in gardening, Atticus takes tremendous pleasure in reading and devotes every evening to the activity. He also teaches his children to indulge in activities they take pleasure in such as reading and shooting. Granted, he additionally teaches them to act with moderation. For example, he states that although he would rather see them shooting after tin cans, he knows they will go after birds and allows them to do so as long as they understand that "it is a sin to kill a mockingbird," meaning it is a sin to kill innocent beings (Ch. 10).

Hence, for those of us who agree with Miss Maudie, we can agree that the belief that pursuing pleasure is a sin is an overly-literal interpretation, perhaps even a misinterpretation, of the Bible.

What is the most abundant mineral family on Earth? Not just Earth's crust.

Let's start with the definition of a mineral. A mineral is a substance that is naturally found in nature, has a specific chemical formula, is usually solid and inorganic, and has a crystalline structure. So, by definition we find minerals in Earth's crust, whether that is the ground we can see or the ground that is below water. 


The vast majority of minerals (about 98-99%) are made up of one or more of 8 different elements. These elements starting with the greatest abundance are oxygen, silicon, aluminum, iron, calcium, sodium, potassium, and magnesium. 


Silicon and oxygen combine very readily to form different silicates, and silicone can combine with other elements to create a wide variety of silicates. One of the most common silicates is quartz, which is SiO2. The secret to the versatility of silicon is that it easily creates bonds with oxygen to form a tetrahedron structure, and these bonds are very strong and stable. From here, other cations can bond as well, creating many different minerals.


Therefore, the silicates are the most common group of minerals on Earth. They make up between 95-97% (these numbers vary depending on the study you are reading, but it is accepted that the percentage is very high) of the Earth's crust and can be found anywhere in the world. 

Thursday, November 26, 2015

What is amebiasis?


Causes and Symptoms


Amebiasis entails infection of the colon by the single-cell parasite
Entamoeba histolytica. The majority of people infected—about 80 to 90 percent—do not develop symptoms and may be chronic carriers, a fact that is difficult to detect. Most of those who are symptomatic experience loose stools, intermittent diarrhea, intensified flatulence, and stomach cramps. Severe cases involve bloody diarrhea (dysentery), abdominal tenderness, mucus in the stool, or fever.



The parasite spreads when a person swallows food or water containing infected feces. Infection occurs in two forms, the active parasite (trophozoite) or dormant parasite (cyst form, which may activate in the intestinal tract). The trophozoites attack the lining of the colon, feeding on bacteria and tissue, and may cause ulcers. Sometimes a lump (ameboma) forms that is large enough to obstruct the intestines.


Occasionally, the trophozoites penetrate the bowel wall and enter the abdominal cavity, causing peritonitis, or they may travel to other organs. The liver may be infected, with the parasite forming an abscess that can cause fever, chills, and weight loss. Much more rarely, the lungs, brain, or skin on the buttocks becomes infected.




Treatment and Therapy

Physicians test for amebiasis by examining three to six stool samples for evidence of the parasite. A colonoscopy may be used to locate ulcers and take a tissue sample. Abscesses in the liver can be located by ultrasound or computed tomography (CT) scan but cannot directly confirm the presence of Entamoeba histolytica.


The standard treatment is to give the patient antibacterial drugs. For those who are not sick, one antibiotic is given; for those with symptoms, there are usually two. The most common combination is metronidazole and iodoquinol, administered orally for ten days. Paromomycin and diloxanide furoate are also used, and for liver abscess, tinidazole. Follow-up tests of stool samples after two to four weeks are used to check for the presence of the parasite, as relapses may occur. Antidiarrheal medications may be needed to help patients control their bowels.




Perspective and Prospects

The vast majority of amebiasis infections occur in countries with poor sanitation or that use human waste as a crop fertilizer. Therefore, amebiasis is a form of travelers’ diarrhea for tourists in Mexico, Central America, parts of South America and Africa, and South Asia. Sexual transmission is possible. Mass outbreaks are rare, but one arose during the 1933 Chicago World’s Fair when contaminated water led to about one thousand symptomatic cases and fifty-eight deaths.




Bibliography:


"Amebiasis." MedlinePlus, Mar. 22, 2013.



Beers, Mark H. The Merck Manual of Medical Information. New York: Pocket Books, 2003.



Ericsson, Charles. Travelers’ Diarrhea. 2nd ed. Hamilton, Ont.: B. C. Decker, 2008.



McCoy, Krisha, and Michael Woods. "Amoebic Dysentery." Health Library, Nov. 26, 2012.



"Parasites - Amebiasis." Centers for Disease Control and Prevention, Nov. 2, 2010.



Parker, James N. The Official Patient’s Sourcebook on Travelers’ Diarrhea. Urbana, Ohio: Icon Health, 2002.



Schwartz, Eli. Tropical Diseases in Travelers. Hoboken, N.J.: Blackwell, 2009.

Wednesday, November 25, 2015

Why is Clarisse jailed by the authorities in Fahrenheit 451 by Ray Bradbury?

In Fahrenheit 451, Clarisse is not jailed by the authorities, but she is a target of surveillance. In Part One, for example, Beatty admits Clarisse's whole family is being watched by the government:



We've a record on her family. We've watched them carefully. Heredity and environment are funny things. You can't rid yourselves of all the odd ducks in just a few years.



In other words, Clarisse and her family are under surveillance because they do not conform to socially-accepted ideas of normality. They are free-thinkers, questioning society and expressing dislike for popular forms of entertainment, like driving fast on the highway.


Bradbury does not make clear what happens to Clarisse when she suddenly disappears. Mildred, for example, tells Montag that she has "gone" and the whole family has moved. Mildred thinks Clarisse is dead but does not know what happened to her. In Part Three, however, Montag suggests Clarisse was a victim of a hit-and-run attack.

What kind of man is Mr. Behrman? Why do you think he has not painted his masterpiece yet? Why did Sue and Mr. Behrman exchange a glance when they...

O. Henry wanted to surprise his reader by having an artist paint a leaf on the nearby brick wall so Johnsy would not die, but would instead recover by emulating the example of the courageous last leaf. The author needed a character who was an artist to paint that leaf, but he did not want the reader to have the slightest suspicion that such a thing might happen. Therefore, O. Henry created a character in Old Behrman who would not be suspected of doing what he actually did do in order to save Johnsy's life. If Johnsy had had a young lover who was a painter, right away the reader would suspect the lover would do something heroic to save her life. The following dialogue is significant. The doctor is talking to Sue outside the sick-room:



"Your little lady has made up her mind that she's not going to get well. Has she anything on her mind?”




“She—she wanted to paint the Bay of Naples some day,” said Sue.




“Paint?—bosh! Has she anything on her mind worth thinking about twice—a man, for instance?”




“A man?” said Sue, with a jew's-harp twang in her voice. “Is a man worth—but, no, doctor; there is nothing of the kind.”



This is intended to obviate the possibility of Johnsy having a young lover who might decide to paint a leaf on the nearby wall. When Old Behrman is introduced, he is the very antithesis of a young lover. You might say that he was created to be such an antithesis and to seem unlikely of performing any such heroic act because of his age, his drinking, and his completely negative attitude toward Johnsy's fantasy about dying when the last leaf falls. O. Henry has to introduce Behrman without making readers suspicious that he could perform the miracle that happens at the end of the story.



“Vass!” he cried. “Is dere people in de world mit der foolishness to die because leafs dey drop off from a confounded vine? I haf not heard of such a thing. No, I will not bose as a model for your fool hermit-dunderhead. Vy do you allow dot silly pusiness to come in der prain of her? Ach, dot poor leetle Miss Yohnsy.”



Sue has to take Behrman upstairs to sketch him because the light is so dim in the old man's room.



Sue pulled the shade down to the window-sill, and motioned Behrman into the other room. In there they peered out the window fearfully at the ivy vine. Then they looked at each other for a moment without speaking.



They look at each other significantly, without speaking, because they have both seen that the ivy vine is practically denuded of all its leaves. If Behrman hadn't come up to Sue's room he wouldn't have seen the vine and might not have been motivated to help.


Another way in which O. Henry eliminates Behrman as a possible savior of the dying girl is by establishing that the German hasn't painted anything in twenty-five years. The reader assumes that he just isn't any good, which is why he drinks so heavily. There are many putatively creative people who are always talking about what they are going to do but never doing it. As a matter of fact, talking about what you are going to create is a good way of talking yourself out of doing it. Behrman finds himself at last when he is motivated by his love and pity for the sick Johnsy. He finally creates the masterpiece he has been talking about for most of his life:



Still dark green near its stem, but with its serrated edges tinted with the yellow of dissolution and decay, it hung bravely from a branch some twenty feet above the ground.



No doubt he dies a happy man.

Tuesday, November 24, 2015

What is nonalcoholic steatohepatitis (NASH)?


Causes and Symptoms

The liver
is a complex organ located in the right upper abdomen. It plays a role in converting carbohydrates, fats, and proteins from food into usable forms for the body. It also manufactures cholesterol, stores sugar, and metabolizes certain medications and chemicals. Nonalcoholic steatohepatitis (NASH) is characterized by the storage of excess fat in the liver, with associated inflammation. The cause of this disorder is not completely understood. The accumulation of excess fat in the liver is related to the body’s inability to use its own insulin, a common problem found in adults and children with central obesity. NASH is also found in individuals with other medical conditions, such as diabetes, metabolic syndrome, high blood pressure, and hyperlipidemia. Other causes of excess fat storage are certain medications, exposure to occupational toxins, and some surgical procedures. The excess fat causes damage to the cells of the liver that is similar to the damage caused by excess alcohol intake.



The majority of people with NASH have no symptoms, and the disorder is suspected from liver function tests. Studies have shown, however, that elevated liver enzymes do not always occur in individuals with NASH. If symptoms are present, then they may include fatigue or mild discomfort in the upper right side of the abdomen. The liver may be enlarged. Fatty liver may be identified on ultrasound, but a biopsy of the liver must be performed in order to determine the extent of the disorder. A liver biopsy
is a minor surgical procedure that is performed by inserting a needle into the liver through a small incision and removing cells for evaluation under the microscope. The disorder may range from inflammation of the liver to cirrhosis, a chronic, progressive disease with extensive scarring of the liver that causes destruction of liver cells. If the destruction advances, then the liver loses the ability to function. Severe liver disease occurs in approximately 20 percent of those with NASH.




Treatment and Therapy

Treatment goals include the identification and treatment of associated conditions and the reduction of insulin resistance. Adopting a healthy lifestyle is the primary treatment for NASH. Those who are overweight are encouraged to lose weight gradually and to exercise. Triglyceride and cholesterol levels should be kept within normal limits. Strict blood sugar control is indicated for diabetics with NASH. A few studies have found that daily vitamin E reduces abnormal liver enzymes. Insulin-sensitizing drugs, normally used by diabetics, have also shown promise for the treatment of NASH and its associated insulin resistance. Lipid-lowering drug studies have also shown some improvement in blood liver function tests, but not in the follow-up biopsy tests for inflammation and damage.


It is generally recommended that individuals with NASH avoid alcohol and certain medications, such as acetaminophen, that may further damage the liver. If the individual develops severe cirrhosis, then a liver transplant
may be necessary to avoid death.




Perspective and Prospects

In 1958, fatty liver disease was first identified in a small group of obese individuals. In 1980, the term nonalcoholic steatohepatitis was coined to describe a small group of patients at the Mayo Clinic who had liver biopsy findings similar to those with alcoholic liver disease. Since 2000, pediatricians have reported the presence of NASH in obese children, as well as in children with other endocrine disorders. The increase in obesity and diabetes in the United States has been linked to the increasing numbers of individuals diagnosed with NASH.


Diagnosis is confirmed with a liver biopsy, or, less commonly, with a noninvasive diagnostic method. Ultrasound and abdominal computed tomography (CT) scans are sometimes used, as are newer x-ray techniques and laboratory blood analyses.


Drug therapy continues to be investigated after promising pilot studies. Further study is also needed in the area of the disease process and its potential for progression in some individuals.




Bibliography:


Adams, L. A., and P. Angulo. “Treatment of Non-alcoholic Fatty Liver Disease.” Postgraduate Medicine Journal, 82 (May, 2006): 315–322.



Harrison, Stephen A., and Adrian M. Di Bisceglie. “Advances in the Understanding and Treatment of Nonalcoholic Fatty Liver Disease.” Drugs 63, no. 22 (2003): 2379–2394.



Howson, Alexandra. "Nonalcoholic Fatty Liver Disease." Health Library, May 14, 2013.



“Liver Disease: Fat Inflames the Liver.” Harvard Health Letter 26 (February, 2001): 4.



Nakajima, Kenichirou, et al. “Pediatric Nonalcoholic Steatohepatitis Associated with Hypopituitarism.” Journal of Gastroenterology 40, no. 3 (March, 2005): 312–315.



"Nonalcoholic Fatty Liver Disease." Mayo Clinic, February 19, 2011.



Nonalcoholic Steatohepatitis." National Digestive Diseases Information Clearinghouse, April 30, 2012.



Porth, Carol M. “Disorders of Hepatobiliary and Exocrine Pancreas Function.” In Pathophysiology: Concepts of Altered Health States. 8th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2010.

Was Emily Dickinson a feminist poet?

Whether Emily Dickinson was a feminist poet depends on the definition of feminism one uses. In one sense, "feminism" means to participate in organized activity advocating for women's rights and interests. In another sense, "feminism" means simply a belief in equal rights and opportunities for women. There is no indication that Emily Dickinson was a feminist in the first sense of the word. Since she lived most of her adult life in a semi-reclusive state, she did not become involved in public efforts for women's suffrage, for instance.


However, one could build a case that Dickinson was feminist in the second sense of the word. Dickinson's poetry deals with a wide variety of topics that affect women and men equally. Her poems about death, grief, nature, faith, and other philosophical topics reflect a woman of high intelligence who was the equal of any male poets writing in her day, or any other day. Interestingly, Dickinson was not beyond assuming a male persona in her poems, as evidenced by "A narrow Fellow in the Grass" (1096), but there are other poems in which the speaker is obviously feminine, such as "I'm wife - I've finished that -" (225). Because of her primary subject matter, her poetry could be considered feminist because it treats men and women equally in that all are equally affected by the issues she writes about.


As far as Dickinson's personal life, she never married but devoted her life to her writing career. Although she published only a few poems in her lifetime, she was an assiduous author, producing nearly two thousand poems. Upon her death, her family found 40 volumes of poems she had bound into fascicles by hand, so she was pursuing her writing career intentionally, even though no one understood at the time to what extent. 


By looking at the subject matter of Dickinson's poetry and considering her personal life, one could make the case that Dickinson was a feminist writer who believed in the equality of the sexes. 

Monday, November 23, 2015

What is the meaning of aim in science?

Aim is a term commonly used in science to define the objective of a process or an experiment. In simple terms, aim defines what a particular process or experiment will accomplish or what information it will provide us with. Aim is generally a brief and succinct statement about a given process. 


For example, if we want to study the effect of increasing sugar quantity on the taste of tea, we can carry out an experiment. In this experiment, we will add successively higher amounts of sugar in a cup of tea and taste it. For such an experiment, the aim can be written as "to determine the effect of sugar quantity on the taste of tea." This single statement will tell anybody what we intend to do with the proposed experiment. 


Sometimes, the term objective is also used interchangeably with aim. 


Hope this helps.

What was the context in which Roosevelt delivered the "Four Freedoms" speech?

After Franklin D. Roosevelt was elected for a third term as President of the United States, something no other President had done, he gave a State of the Union speech that became known as the “Four Freedoms” speech. As we entered January 1941, much of the world was at war. President Roosevelt could see that the way events were unfolding, we were likely heading for an entrance into the war on the side of the Allies.


President Roosevelt knew if we joined World War II, we would be helping Great Britain fight against Germany, Italy, and Japan. President Roosevelt wanted to make the argument for entering the war by indicating how we needed to fight to protect four basic freedoms everybody should have. These freedoms were freedom from fear and want as well as freedom of speech and worship. President Roosevelt also knew we needed to support Great Britain because they were fighting against countries that were taking away these four freedoms from their people. President Roosevelt knew our fate was tied to Great Britain’s fate. President Roosevelt also knew we had to continue to help Great Britain before we entered the war.


President Roosevelt knew he had to prepare the American people as well as Congress for all of these scenarios. This speech was one way he could do that.

Sunday, November 22, 2015

Was Manifest Destiny wrong, or was it our right as Americans to go from sea to shining sea?

There are two ways to look at the concept of Manifest Destiny. One way was very supportive of this policy while the other view felt it was wrong for us to follow this policy.


Manifest Destiny is a term that describes the growth and expansion of our country. There were people who believed it was our duty or destiny to spread from the Atlantic Ocean to the Pacific Ocean and to control and develop this land. These people argued that it was part of G-d’s plan for this to happen. They believed our way of life was better than anybody else’s way of life. They argued that G-d put us here to spread our way of living.


Other people believed no group of people ever had a right to any area of land, especially if that land belonged to somebody else. They argued that is was wrong for us to take away the land on which the Native Americans lived. They believed we had no right to impose our way of living or our way of doing things on another group of people. They felt that it was wrong for the United States to expand at the expense of other countries or other groups of people.

If the angle of reflection is 90 degrees for a light ray, what is its angle of incidence?

According to the law of reflection, angle of incidence and angle of reflection are equal. Angle of incidence is the angle an incident light ray makes with a normal drawn to the surface. Similarly, angle of reflection is the angle made by the reflected ray with a normal drawn to the reflecting surface.


In other words, angle of incidence = angle of reflection


Since, the angle of reflection in the given case is 90 degrees, the angle of incidence can be calculated as:


angle of incidence = angle of reflection = 90 degrees.


Thus, an angle of reflection of 90 degrees is caused by an incident ray that has an angle of incidence of 90 degrees.


An angle of reflection of 90 degrees means that the reflected ray travels along the surface. This is because the incident ray is also traveling along the reflecting surface. 


Hope this helps. 

Saturday, November 21, 2015

Why didn't Karana build her house near the sea elephants in Island of the Blue Dolphins?

When Karana made the decision to build a more permanent home on the island, she narrowed her search based on three criteria. She wanted her home to be protected from wind and weather, near a spring providing fresh water and close to Coral Cove.


She quickly dismissed one, that near her old village of Ghalas-at. She decided against it because she didn't want to live with a constant reminder of her lost people, and it was also very windy there.  


This left her with two choices, the headland where she had been staying thus far and another area farther to the west. When she went to investigate the other area she remembered that it was near the lair of the wild dogs, and though she planned to kill them, she didn't want to have to accomplish that task before she could build her house. On a positive note, the spring was more appealing than the one near the headland as it was easier to access, was less brackish and had a better water flow. The location was also suitable as it was close to a rocky cliff that would provide protection from the wind, and allow her to see the north shore and Coral Cove.


The final factor that swayed Karana's decision was the sea elephants. This area was on a cliff above the coast where the sea elephants gathered to fish, take refuge during a storm, and sun themselves on the rocks. The day Karana explored the area, the group of sea elephants was far away due to low tide; however the collection of them made an overwhelming noise of barking, screaming and chattering. Karana stayed to continue her exploration for the remainder of the day and slept there that night too. When the sea elephants' incessant uproar started again early the next morning, Karana made the decision to build her home in the more peaceful setting of the headland.

Friday, November 20, 2015

How does Vera's story about Mrs. Sappleton's husband and brothers affect Mr. Nuttel's internal conflict?

Framton Nuttel suffers from a nervous condition and is possibly a hypochondriac. He may have a legitimate neurological condition and it may be psychosomatic. In either case, he is quite easily affected by Vera's story. Vera tells the story that her aunt's husband and brothers left through the window three years ago and never returned. They were presumed dead. Vera ends with, "Do you know, sometimes on still, quiet evenings like this, I almost get a creepy feeling that they will all walk in through that window—” 


When Vera's aunt walks into the room, Mr. Nuttel is relieved. However, Ms. Sappleton then tells him she expects her husband and brothers to return soon. Mr. Nuttel is horrified by this.



To Framton, it was all purely horrible. He made a desperate but only partially successful effort to turn the talk on to a less ghastly topic; he was conscious that his hostess was giving him only a fragment of her attention, and her eyes were constantly straying past him to the open window and the lawn beyond.



He tries to change the subject and relates that he is supposed to avoid all mental and physical exertion. Then the husband and brothers return and Mr. Nuttel leaves in a hurry. But it is Vera's story that sets up his horrified need to escape. One could argue that Vera is malicious in this practical joke. On the other hand, Mr. Nuttel is just too impressionable and too gullible. What are the odds that he would arrive on the alleged tragic anniversary? He never considers that this coincidence is suspicious. When he feels uncomfortable, he starts talking about himself and his ailments. Vera's story easily plays with his vulnerable and sensitive tendencies. Vera is a gifted storyteller/liar, but Mr. Nuttel's weak mental state makes it easy for her to fool him.

Thursday, November 19, 2015

What is Marburg hemorrhagic fever?


Causes and Symptoms

Marburg hemorrhagic fever is caused by a filovirus. Filoviruses are separated into two distinct types, Marburg and Ebola. All filoviruses are classified as biosafety level 4 agents based on their high mortality rate, potential transmissibility, and the absence of effective vaccines or treatments. The systemic nature of filovirus infections suggest they may have immunosuppressive effects.



Human-infecting viruses usually appear as small, round, or oval organisms. Filoviruses are unique among human viruses, appearing as long, cylindrical organisms with twists and loops. The natural
reservoir for filoviruses is unknown but is presumed to be wild animals (zoonotic). Research suggests that filoviruses may possibly be linked to fruit bats, from which the viruses are occasionally introduced into primate populations. The primary transmission of Marburg filovirus from its natural reservoir appears to occur only in sub-Saharan Africa within five degrees of the equator.


Human transmission of Marburg hemorrhagic fever is by direct contact with infected blood, semen, urine, mucus, and organs. Some evidence suggests that aerosol transmission may also occur. The virus enters the body through lesions and initially infects the lymph nodes, spleen, and liver. Marburg filovirus can survive several weeks in corpses and blood samples.


The incubation period of Marburg hemorrhagic fever is two to twenty-one days after infection, and symptoms include high fever, severe headache, painful sore throat, rashes, muscle pain (myalgia), inflamed lymph nodes, dementia, and bloody vomiting and diarrhea from internal hemorrhaging. Symptoms usually progress to bleeding from the gums and nose, puncture openings in the skin, small hemorrhages in the whites of the eyes, and eventual red blood cell immobilization. Hair, skin, and nail loss, as well as searing body pain from inflamed nerves, occur in later stages of infection. The infection may last as long as three weeks and is often described as agonizing. In fatal cases, the patient’s blood pressure undergoes a final severe drop resulting in shock prior to death.




Treatment and Therapy

There is no vaccine or specific therapy available for filoviral infections, although several vaccines and drug therapies are currently being tested. Specific symptoms are treated during the course of infection; the patient either responds or does not. Secondary prevention requires total isolation of infected patients. Primary infected patients show a higher mortality rate than do secondary infected patients. The mortality rate for humans infected with Marburg hemorrhagic fever ranges from 24 to 88 percent, with some outbreaks being more deadly than others.




Perspective and Prospects

Marburg hemorrhagic fever was first described in 1967 during outbreaks at research laboratories in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia, and linked to African green monkeys imported for research purposes from Uganda. Since the initial outbreaks, sporadic cases of Marburg hemorrhagic fever have been identified in eastern and southern Africa, with the largest outbreaks occurring in the Democratic Republic of the Congo in 1998 and in Uganda in 2012. One of the most frightening aspects of Marburg hemorrhagic fever is its ongoing inclusion in some nations’ biological weapons programs.




Bibliography:


Garrett, Laurie. The Coming Plague: Newly Emerging Diseases in a World out of Balance. New York: Penguin, 1995.



Klenk, Hans-Dieter, ed. Marburg and Ebola Viruses. New York: Springer, 1999.



Levy, Elinor, and Mark Fischetti. The New Killer Diseases: How the Alarming Evolution of Mutant Germs Threatens Us All. New York: Crown, 2003.



"Marburg Haemorrhagic Fever." World Health Organization, November 2012.



"Marburg Hemorrhagic Fever Fact Sheet." Centers for Disease Control and Prevention, April 23, 2011.



Mayo Clinic Staff. "Ebola Virus and Marburg Virus." Mayo Clinic, June 18, 2011.



McCormick, Joseph B., Susan Fisher-Hoch, and Leslie Alan Horvitz. Level 4: Virus Hunters of the CDC. Rev. ed. New York: Barnes & Noble, 1999.

Wednesday, November 18, 2015

What is Ewing sarcoma?





Related conditions:
Primitive neuroectodermal tumor, peripheral primitive neuroectodermal tumor, Askin’s tumor, osteosarcoma






Definition:

Ewing sarcoma is a rare disease involving cancer cells found in bones and soft tissue. It usually occurs in the pelvis, ribs, arm bone (humerus), shoulder blade, or leg bone (femur). It gets its name from James Ewing, who in the 1920s first described the disease as being separate from other known types of cancers such as lymphoma or neuroblastoma. Ewing noticed that this type of cancer responded well to radiation. It belongs to a group of tumors sometimes called the Ewing family of tumors because of the close molecular relationship between these kinds of tumors.




Risk factors: More than 90 percent of people who develop this disease have an unusual rearrangement between chromosomes: A piece of chromosome 11 and a piece of chromosome 22 have switched places (called a gene translocation). However, this translocation is not inherited or passed on genetically, so family members of those affected with Ewing sarcoma have no more risk of developing the cancer than the general population does.


Male teenagers are most often diagnosed with this disease. The cancer is thought to be linked somehow to the rapid growth that occurs during puberty. Whites are more likely to develop this disease than are Asians and African Americans. MedlinePlus reported in 2014 that Ewing sarcoma is ten times as common in Caucasian children as in children of African or Asian descent.


Very rarely, Ewing sarcoma can develop as a secondary tumor in patients who have had radiation therapy for another type of cancer.



Etiology and the disease process: Because this cancer occurs most often during the teenage years, there may be a link between the onset of puberty and early stages of this disease.


Ewing sarcoma usually starts in a bone, though it can start in soft tissue. The most common starting place for these tumors is in the pelvis or in the leg bones. The tumors may then spread to the chest cavity, other bones, bone marrow, lungs, kidneys, or heart when tumor cells enter the bloodstream and travel elsewhere in the body. This disease may also spread to the central nervous system or lymph nodes, but this is much less common.



Incidence: This disease occurs most often in male children and teenagers, mostly between ten and twenty years old. However, female children and teenagers also develop this disease. In the United States, this cancer affects children less than three years of age at a rate of 0.3 per million and teenagers between the ages of fifteen and nineteen at a rate of 4.6 per million. People over the age of twenty-five rarely develop this type of cancer. In 2014 the American Cancer Society estimated that in North America each year about 225 new cases of this cancer are diagnosed in children and teens. These tumors make up about 30 percent of the bone cancers in children; the American Cancer Society reported in 2014 that about 1 percent of all childhood cancers are Ewing sarcoma.



Symptoms: Symptoms of Ewing sarcoma involve pain (which may be worse at night), swelling (especially when the tumor is located in the long bones of the arm or leg), redness, tenderness, stiffness, a mass that grows quickly and may feel warm, or a bone that breaks unexpectedly. Some patients have fever, fatigue, anemia, or weight loss. Numbness, tingling, or paralysis can also be symptoms if the tumor is located near nerves.



Screening and diagnosis: Because this disease is so rare, no screening is recommended. When Ewing sarcoma is suspected, doctors generally use x-rays to determine if there is a suspicious growth. A magnetic resonance imaging (MRI) scan or blood tests also may be helpful in making a diagnosis. If Ewing sarcoma is suspected, two additional tests are used to see if the disease has spread: a computed tomography (CT) scan, which usually includes the lungs to see if the disease has spread there, and a bone scan.


Ewing sarcoma may initially be mistaken for a bone infection (osteomyelitis) or another type of bone cancer (osteosarcoma). A sample of the tumor (biopsy) is necessary to confirm the diagnosis of Ewing sarcoma. A biopsy may be performed with a fine needle, taking only a small sample of the tumor, or by surgery, where all or a large part of the tumor is removed. Sometimes, bone marrow also is biopsied to determine if the disease has spread there.


There is no formal staging for Ewing sarcoma. Gauging the extent of this disease is done by simply determining whether the cancer has spread into other tissues.



Treatment and therapy: Ewing sarcoma is usually a very aggressive disease. By the time of diagnosis, nearly all patients with Ewing sarcoma have some spreading of the disease throughout the body. Most patients are treated with chemotherapy, sometimes before and after surgery, to ensure treatment of any tumors throughout the body.


Surgery or radiation may also be used at the local site of the main tumor if the tumor can be removed without damaging vital organs. Sometimes surgery involves removing bones, which can be replaced or rebuilt with artificial bones or bone grafts. With Ewing sarcoma, radiation therapy usually involves radiation that comes from a machine outside the body rather than from implanted radiation seeds. Radiation therapy can shrink large tumors to alleviate symptoms if the tumor cannot be removed with surgery.


Other types of treatment may include rehabilitation, including occupational or physical therapy. Patients may also need supportive care to help with side effects of chemotherapy, radiation, or surgery. Some patients may benefit from a transplant of blood stem cells or bone marrow.


Diagnosis of Ewing sarcoma usually occurs during the teenage years, sometimes an already turbulent period. Surgery may cause disfigurement during a period of life when looks are very important. Support groups in which teens meet other people with this condition may be especially helpful in dealing with the psychological trauma that this disease can cause.


Generally, patients with Ewing sarcoma benefit from treatment at a children’s hospital or medical center with doctors who have experience treating pediatric cancers.



Prognosis, prevention, and outcomes: The prognosis for patients with this disease depends on how far the disease has spread, the size and location of the main tumor, and how responsive the tumors are to chemotherapy. For patients who at diagnosis show no signs of the spread of the disease and choose an aggressive course of treatment involving chemotherapy, surgery, and radiation, survival rates at five years are 70 to 75 percent (ACS, 2014). However, at diagnosis, at least 15 percent of these patients already have cancer throughout their bodies, generally because symptoms are so vague and nonspecific. These patients have a five-year survival rate of 15 to 30 percent (ACS, 2014). Children under the age of ten, female children and teenagers, those with smaller tumors, and those who have tumors below the elbow or below the calf have the highest survival rates.


People who have had Ewing sarcoma need continual follow-up care. Even if the cancer is treated and its spread stopped, it often develops again in the place where it first arose and tends to spread throughout the body. Health issues may spring up later that are caused by the type of treatment given. These issues may involve heart and lung problems, slowed or decreased growth and development, and problems with sexual development. It is important for a patient who has had this disease to be regularly monitored for these types of concerns.


There is no known way to prevent Ewing sarcoma. However, not everyone with the gene translocation develops this disease. Scientists are investigating why the gene translocation causes the disease only in some people to see if there are ways to block this cancer from forming. Research is also under way to determine new and improved techniques for diagnosing this cancer earlier in the disease process.



Amer. Cancer Soc. "Ewing Family of Tumors." Cancer.org. ACS, 2014. Web. 21 Oct. 2014.


Chen, Yi-Bin. "Ewing Sarcoma." MedlinePlus. US NLM/NIH, 23 Mar. 2014. Web. 21 Oct. 2014.


Machado, Isidro, et al. "Biomarkers in the Ewing Sarcoma Family of Tumors." Current Biomarker Findings 4 (2014): 81–91. Digital file.


Natl. Cancer Inst. "Ewing Sarcoma Treatment (PDQ(R))." Cancer.gov. NCI/NIH, 8 Oct. 2014. Web. 21 Oct. 2014.


Pappo, Alberto S., ed. Pediatric Bone and Soft Tissue Sarcomas. New York: Springer, 2006. Print.


Parker, Philip M., and James N. Parker. Ewing’s Sarcoma: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. San Diego: ICON Health, 2004. Digital file.


US Natl. Lib. of Medicine Genetics Home Reference. "Ewing Sarcoma." Genetics Home Reference. US NLM/NIH, 20 Oct. 2014. Web. 21 Oct. 2014.


Theroux, Nicole, et al. Ewing’s Sarcoma Family of Tumors: A Handbook for Families. 1999. Glenview: Assoc. of Pediatric Oncology Nurses (US), 2006. Print.

What is polygenic inheritance?


Discovery of Polygenic Inheritance

Soon after the rediscovery of Gregor Mendel’s laws of heredity in 1900, Herman Nilsson-Ehle, a Swedish geneticist, showed in 1909 how multiple genes with small effects could collectively affect a continuously varying character. He crossed dark, red-grained wheat with white-grained wheat and found the progeny with an intermediate shade of red. Upon crossing the progeny among themselves, he obtained grain colors ranging from dark red to white. He could classify the grains into five groups in a symmetric ratio of 1:4:6:4:1, with the extreme phenotypes being one-sixteenth dark red and one-sixteenth white. This suggested two-gene segregation. For a two-gene (n = 2) model, the number and frequency of phenotypic classes (2n + 1 = 5) can be determined by expanding the binomial (a + b)4, where a represents the number of favorable alleles and b represents the number of nonfavorable alleles.











Subsequently, Nilsson-Ehle crossed a different variety of red-grained wheat with white-grained wheat. He found that one-sixty-fourth of the plants produced dark red kernels and one-sixty-fourth produced white kernels. There were a total of seven phenotypic (color) classes instead of five. The segregation ratio corresponded to three genes: (a + b)6 = 1a
6 + 6a
5
b
1 + 15a
4
b
2 + 20a
3
b
3 + 15a
2
b
4 + 6a
1
b
5 + 1b
6. Here, a
6 means that one of sixty-four individuals possessed six favorable alleles, 20a
3
b
3 means that twenty of sixty-four individuals had three favorable and three nonfavorable alleles, and b
6 means that one individual had six nonfavorable alleles. An assumption was that each of the alleles had an equal, additive effect. These experiments led to what is known as the multiple-factor hypothesis, or polygenic inheritance (Kenneth Mather coined the terms “polygenes” and “polygenic traits”). Around 1920, Ronald Aylmer Fisher, Sewall Green Wright, and John Burdon Sanderson Haldane developed methods of quantitative analysis of genetic effects.


Polygenic traits are characterized by the amount of some attribute that they possess but not by presence or absence, as is the case with qualitative traits that are controlled by one or two major genes. Environmental factors generally have little or no effect on the expression of a gene or genes controlling a qualitative trait, whereas quantitative traits are highly influenced by the environment and genotype is poorly represented by phenotype. Genes controlling polygenic traits are sometimes called minor genes.




Examples and Characteristics of Polygenic Traits

Quantitative genetics encompasses analyses of traits that exhibit continuous variation caused by polygenes and their interactions among themselves and with environmental factors. Such traits include height, weight, and some genetic defects.


Diabetes and cancer are considered to be threshold traits because all individuals can be classified as affected or unaffected (qualitative). They are also continuous traits because severity varies from nearly undetectable to extremely severe (quantitative). Because it is virtually impossible to determine the exact genotype for such traits, it is difficult to control defects with a polygenic mode of inheritance.




Detection of Genes Controlling Polygenic Traits

The detection of genes controlling polygenic traits is challenging and complex for the following reasons.





The expression of genes controlling such traits is modified by fluctuations in environmental and/or management factors.



A quantitative trait is usually a composite of many other traits, each influenced by many genes with variable effects.



Effects of allele substitution are small because many genes control the trait.



Expression of an individual gene may be modified by the expression of other genes and environment.


Polygenic traits are best analyzed with statistical methods, the simplest of which are estimation of arithmetic mean, standard error, variance, and standard deviation. Two populations can have the same mean, but their distribution may be different. Thus, one needs information on variances for describing the two populations more fully. From variances, effects of genes can be ascertained in the aggregate rather than as individual genes.


The issues in quantitative genetics are not only how many and which genes control a trait but also how much of what is observed (phenotype) is attributable to genes (heritability) and how much to the environment. The concept of heritability in the broad sense is useful for quantitative traits, but heritability itself does not give any clues to the total number of genes involved. If heritability is close to 1.0, the variance for a trait is attributable entirely to genetics, and when it is close to zero, the population’s phenotype is due entirely to the variation in the underlying environment. Environmental effects mask or modify genetic effects.


Distribution or frequency of different classes in segregating populations—for example, F2—may provide an idea about the number of genes, particularly if the gene number is small (say, three to four). Formulas have been devised to estimate the number of genes conditioning a trait, but these estimates are not highly reliable. Genes controlling quantitative traits can be estimated via use of chromosomal translocations or other cytogenetic procedures. The advent of molecular markers, such as restriction fragment length polymorphisms, has made it easier and more reliable to pinpoint the location of genes on chromosomes of a species of interest. With much work in a well-characterized organism, these polygenes can be mapped to chromosomes as quantitative trait loci.




Key terms



heritability

:

the proportion of the total observed variation for a trait attributable to heredity or genes




meristic trait

:

traits that are counted, such as number of trichomes or bristles




quantitative trait loci (QTLs)

:

genomic regions that condition a quantitative trait, generally identified via DNA-based markers




quantitative trait

:

a trait, such as human height or weight, that shows continuous variation in a population and can be measured; also called a metric trait




threshold traits

:

characterized by discrete classes at an outer scale but exhibiting continuous variation at an underlying scale; for example, diabetes, schizophrenia, and cancer





Bibliography


Jurmain, Robert, et al. “Heredity and Evolution.” Introduction to Physical Anthropology. 13th ed. Florence: Wadsworth, 2011. Print.



Kang, Manjit S. Quantitative Genetics, Genomics, and Plant Breeding. Wallingford: CABI, 2002. Print.



Khoury, M. J., A. C. J. W. Janssens, and D. F. Ransohoff. "How Can Polygenic Inheritance Be Used in Population Screening for Common Diseases?" Genetics in Medicine 15.6 (2013): 437–43. Global Health. Web. 7 Aug. 2014.



Krimsky, Sheldon, and Jeremy Gruber. Genetic Explanations: Sense and Nonsense. Cambridge: Harvard UP, 2013. Print.



Lynch, Michael, and Bruce Walsh. Genetics and Analysis of Quantitative Traits. Sunderland: Sinauer, 1998. Print.



Young, Ian D. “Polygenic Inheritance and Complex Diseases.” Medical Genetics. New York: Oxford UP, 2005. Print.

What did Rosh think was more important than the life of the old miser?

In chapter 9 of The Bronze Bow, Daniel is pleased that Rosh has given him a solo job to perform for the band. He is to ambush an old miser and steal his money. Daniel jumps the man and knocks him out, taking his money bag and two knives. However, as he walks away, he looks back and sees the old man lying on the road. The man reminds him of his grandfather, and Daniel can't leave him lying there defenseless. He pulls the man off the road into some shade and waits for him to regain consciousness. He then returns one of the knives to the man. 


Rosh reprimands Daniel, saying he should have killed the miser. Now the miser represents a threat to Daniel if he ever sees him in the city. Rosh explains to Daniel that the man should have been killed for the good of the country. The miser's money will go to pay the men Rosh intends to recruit to overthrow the Romans. Since the man will not support the liberation of his country any other way, being killed to support Rosh and his band was a higher service than he was performing by remaining alive. Rosh concludes his argument by saying, "And what loss would it have been--one old man more or less?" So to Rosh, the man's money, which would be used to support the men who will fight the Romans, is more important than his life.


Daniel at first succumbs to Rosh's logic, but later a nagging doubt plagues him. He realizes the stark contrast between Rosh's view of life and Jesus' view. Rosh values people only for what he can use them for, but to Jesus, every man is "a child of God." Jesus, Daniel suspects, does not think a man's money or usefulness as "a tool or weapon" is more important than his life. 

How did the world in "The Pedestrian" come to be? What will happen to Leonard?

Bradbury does not give a specific reason or series of events that explains how and why the world came to be the way that it is in the story.  Bradbury simply created a world in which people are glued to their electronic devices inside their homes.  Because the people do that so much, there is no need for much of a police force.  Nobody goes outside anymore.  There is nothing to police.


 I don't feel that Bradbury's world is that strange of a prediction.  I teach a high school media studies course, and for ten years I have been tracking data on the growing rates of media consumption.  I've posted the link to an October 2015 study.  It divides media usage up by category and shows that Americans watch more than four hours of TV per day.  That's actually down from previous years, but computer and phone uses are up, and the total consumption is up.  In a typical day, an American uses and consumes twelve hours of media.  That's more time than people spend sleeping or at their normal eight hour per day job.  And usage keeps climbing for digital media every year.  It also has consistently declined for print media.  The world in "The Pedestrian" is a believable world, because current trends reflect the story's world.  


As for what happens to the main character, the police officer says that he will be taken to a psychiatric facility.  



The car hesitated, or rather gave a faint whirring click, as if information, somewhere, was dropping card by punch-slotted card under electric eyes. "To the Psychiatric Center for Research on Regressive Tendencies."



Likely, Leonard will be asked a battery of questions about his "odd" habits.  The employees will probably think him crazy and admit him as a full time resident.  While there, Leonard will probably have nothing to do except watch whatever TV screen happens to be on in whatever room he is placed.  

In Chapter 1, the prescription given by the doctor for Jim's treatment leaves us in no doubt that Jim is a hypochondriac. Elaborate.

In Chapter One, Jim has gone to see his doctor because of a strange predicament: after having read up on a myriad of diseases from a book at the British Museum, Jim concludes that he does not have 'housemaid's knee,' the only disease in the book he has not been inflicted with.


Convinced that he has, by equal turns, suffered from every known malady in the book, Jim resolves to settle the conundrum with his doctor. After all, up until then, Jim had always believed he was unique from a medical point of view.



I thought what an interesting case I must be from a medical point of view, what an acquisition I should be to a class!  Students would have no need to “walk the hospitals,” if they had me.  I was a hospital in myself.  All they need do would be to walk round me, and, after that, take their diploma.



His doctor's prescription involves Jim ingesting a pound of beefsteak with a pound of bitter beer every six hours, along with the admonition to take a ten mile walk each morning, to go to bed at eleven sharp each night, and to refrain from reading copious amounts of medical material. Prior to writing out his prescription, Jim's doctor hits Jim in the chest and butts him with the side of his head.


In Jim's own words, he follows the prescription to the letter and testifies that his life was preserved as a result. Basically, if Jim had really been ill, the doctor would have prescribed medicine a pharmacist would have been able to dispense. However, since Jim is not physically ill and is only fond of supposing himself beset with all sorts of ailments, the prescription purposefully treats his hypochondriac tendencies. The last line of the prescription is telling: the doctor orders Jim to stop filling up his imagination with medical material likely to exacerbate his paranoid inclinations. We are left in no doubt that Jim is a hypochondriac, as this last line of the prescription addresses the characteristic propensities of one who suffers from an overactive imagination rather than a genuine physical malady.

Tuesday, November 17, 2015

What is sports medicine?


Science and Profession

Sports medicine is a field that has become popular as the number of people who exercise has increased. There has been a growing trend of participation in exercise as more and more studies have proved that exercise is beneficial to health; however, exercise places people at risk for injuries that a sedentary person would not have. This fact has led to the emergence of sports medicine, with its specially trained health care professionals. These professionals include physical therapists, athletic trainers, nutritionists, exercise physiologists, cardiologists, sports psychologists, family practitioners, internists, and orthopedic surgeons. They all contribute by bringing special knowledge and understanding to the care of athletes and athletic injuries. Such knowledge can relate to nutrition, strength training, cardiovascular conditioning, psychosocial issues, musculoskeletal care, and many other areas related to the health of athletes. Therefore, sports medicine is a very broad and diverse field that requires a team approach.



Athletic injuries occur with regularity, but very few injuries are unique to sports. Yet treating an injured athlete does not necessarily require the same process used to treat an injured sedentary person. The athlete tends to have greater expectations than does the average sedentary person. These expectations usually increase proportionately with the competitive level of the athlete. For example, the athlete with an ankle sprain will spend ten to twelve hours per day performing treatment and rehabilitation supervised by a physical therapist or athletic trainer. The sedentary person, however, might go to physical therapy three times per week. Although the philosophy of the treatment is the same, the number of treatments and the desired outcomes are completely different. Athletes also require an extensive amount of information regarding their injuries, treatment, and rehabilitation. Athletes are not afraid to ask questions regarding their injuries because they want to know when they will be able to return to competition. The average patient, however, is quite uncomfortable asking the physician about an injury or illness.


Sports medicine is a challenging and rewarding profession. It is enjoyable working with patients who have a high level of compliance and motivation. The reward of watching an athlete recover from an injury and compete is exceptional. The sports medicine physician must realize, however, that he or she will also be called upon by the athlete and the athlete’s coach and parents to communicate the severity of the injury and its significance—a process that can be quite difficult at times, especially when what the physician has to say is not what anyone wants to hear. Nevertheless, it is the role of the physician to act in the best interest of the athlete. In order for the physician to be prepared to handle this, he or she must fully understand the demands of each and every sport. Attendance at games is usually not enough to achieve this level of knowledge and experience. Observing practice sessions and workouts is often quite useful. With the exception of high-impact collision sports such as hockey and football, most injuries occur during practice and workout sessions. Furthermore, such observation gives the physician an opportunity to be involved in education and injury prevention. Many athletic injuries are witnessed by an athletic trainer or physician who may be called upon to administer first aid in the field or, in some instances, provide treatment for injuries.


By attending practices or competitions, the physician may also have the opportunity to observe the actual mechanism of injury, which can be quite useful in evaluating the type and severity of the injury. Many physicians call the first twenty minutes after an injury has occurred, prior to the onset of swelling and spasm, the “golden period.” It is at this time that an accurate and meaningful physical examination can be performed on the injured athlete. The recreational athlete, however, usually will arrive at the physician’s office one to two days after the injury, when swelling and spasm are maximal. At this time, examining the injured body part is quite difficult and may not be meaningful. This may result in delays in diagnosis and definitive treatment. For the sedentary person and the occasional athlete, such delays will probably not be significant. The highly competitive athlete, however, would be quite dissatisfied if an injury delayed his or her return to competition. So, although most athletic injuries differ very little from other cases of musculoskeletal trauma, the finer points of managing them are unique.


Most athletic injuries affect one of three structures in the body: bones, ligaments, or musculotendinous units. These injuries may be acute or chronic in onset. Most acute injuries occur as a result of trauma, with presentation being rather soon after the incident. Chronic injuries, which are often insidious in onset, usually result from a change in the athlete or the athletic environment. Chronic injuries tend to be difficult to recognize and treat effectively. The best approach to chronic injuries is prevention. Most acute injuries can be classified as sprains, strains, or fractures, and most chronic injuries can be classified as strains or stress fractures.


Sprains are injuries to ligaments; strains are injuries to the musculotendinous unit. Sprains occur when there is excessive abnormal motion at a joint. This results in overstretching of the ligaments and produces local pain, swelling, limitation of motion, and a sense of instability. Such overstretching can result in partial tears (mild) or complete tears (severe) of the ligament. Strains are usually the result of an abrupt increase in the tension of the musculotendinous unit (for example, they may occur when one lifts weights that are too heavy). This increase may result in partial or complete tears of the muscle, the tendon, or the bone to which the tendon is attached. The most important principle is to realize that strains are not the result of overstretching but occur well within the normal limits of motion. Strains are also graded from mild to severe. Often, there is an obvious deformity at the site of injury because the muscle rolls up into a ball. Fractures are simply breaks in the bones of the body. Stress fractures occur when excessive demands are placed on the bone. Eventually, the bone fails to accommodate these demands, and microscopic breaks result.




Diagnostic and Treatment Techniques

The initial management of acute injuries is the same in athletics as it is in other musculoskeletal trauma. Treatment should be directed at prevention of bleeding and edema. These conditions usually lead to pain and decreased function of the injured body part, which requires the application of ice, compression, elevation, and rest. There are other methods of treatment used in the professional setting that are also useful in preventing or reducing bleeding and edema. These include electric stimulation, contrast baths, ultrasound, and compression stockings. After the initial phase of bleeding and edema, therapy should be directed at restoring range of motion, strength, and, finally, functional tasks that will ultimately result in the athlete’s return to competition. Chronic injuries, however, usually require elimination of the precipitating factors as well as increased rest while the injured body part is allowed to heal. This may require a special taping procedure, a brace, a change in footwear, the alteration of practice sessions, or simply refraining from that activity for a short period of time.


Chronic injuries and overuse injuries are usually caused by change. Change can occur in the athlete, the environment, or the activity. Identifying these changes can be helpful in injury prevention, since the majority of injuries in athletics are chronic. Also, the treatment requires elimination of the offending change and restoration of the proper condition. Strains to the musculotendinous unit can also occur chronically. They tend to result from muscle fatigue, too much training too fast, or poor training conditions. Many of these injuries are called tendinitis, which means inflammation of the tendon. The most prominent aspect of such an injury is pain. The pain is almost always located in the region of the injured structure. Management is directed at avoidance of painful activity, elimination of the offending factor, and symptomatic relief of pain with ice, ultrasound, injections, electric stimulation, and medicines. Rehabilitation is aimed at restoring strength and flexibility as well as avoiding the initial cause.


Most sprains can be treated with routine physical therapy and rehabilitation, but many severe sprains will require surgery. Average time lost from athletics ranges from seven days (for example, for a mild ankle sprain) to one year (for example, for a severe knee sprain with reconstruction of ligaments). With strains, complete tears of the tendon usually require surgery, while injury to the muscle itself does not. Treatment is similar to that for sprains; rehabilitation should be directed at regaining strength and flexibility. The diagnosis of a fracture can be made only with the aid of an x-ray picture. Treatment of fractures requires immobilization in a cast, special splint, or brace. Some fractures will require the placement of plates or screws by an \orthopedic surgeon. Rehabilitation of fractures involves restoration of motion, strength, flexibility, and proprioception. Proprioception is simply the unconscious awareness of where a body part is in space (for example, a person can tie his or her shoes with eyes closed because the brain knows where the hands are in space). The treatment of stress fractures is different from treatments of other fractures in that immobilization is almost never necessary. Adaptation of activity and relative rest are usually all that is required. Return to competition averages three to six weeks but may be longer.


Sports medicine personnel also provide education and guidance to coaches, athletes, and parents. They make themselves available to provide the best and most efficient care possible. It is the responsibility of the sports medicine physician to coordinate this care. This all begins with the preseason screening history and physical exam.


Prior to the commencement of each athletic season, athletes are usually required to provide a medical history and undergo a physical examination. The requirements of such examinations vary from state to state, college to college, and professional league to professional league. The purpose of these examinations is to identify athletes who may have potential problems in the sport in which they have chosen to compete.


For example, Johnny is a thirteen-year-old high school freshman trying out for the football team. The doctor listens to his heart and lungs and hears a small heart murmur. The physician recommends that Johnny see a cardiologist prior to beginning football practice. A further workup by the cardiologist reveals that Johnnie has a condition in which the arteries that supply his heart are abnormal. The cardiologist recommends that Johnny not participate in athletic activity that requires stress on the heart. Although this scenario is uncommon, it is a perfect example of the benefits of preseason history and physical exams. Johnny could have died as a result of his condition if it had gone unnoticed.


The preseason screening also identifies athletes who are at risk for developing strains and sprains because their flexibility is lower than normal. Identifying these athletes allows the athletic trainer to work with them on a stretching program intended to reduce the number and severity of such injuries. It is during the preseason that the athletes are at greatest risk for injury, since the workouts are long and numerous and most athletes are not yet in shape. Injuries may occur at any time during practice or a game. Most injuries occur during practice, however, and especially at the end of the session, because athletes are tired and their concentration level is low.


Dean is a twenty-year-old junior college soccer player who is kicked in the side during a slide-tackling drill. He is taken out of practice by the coach and then sent to the training room to see the athletic trainer. The athletic trainer astutely examines Dean’s urine and finds blood in it. Also, he finds that Dean’s blood pressure is somewhat low and that his heart rate is mildly elevated. Because of this, the trainer is concerned about injury to Dean’s kidney or spleen. He promptly phones the team physician, who advises that they meet him in the emergency room at the hospital. After being evaluated by the team doctor, Dean is brought to the operating room by a surgeon, who removes Dean’s extensively damaged spleen. Dean recovers quickly and returns to exercise within six weeks but is not allowed to play soccer until the following season. Without the aid of the trainer and prompt attention by the team physician, Dean might not have had such favorable results.


Mary is a fifteen-year-old high school all-state cross country runner. She is now entering her junior year and is expected to compete on the national level. Mary is also an excellent student and has always been an overachiever. Six weeks into the fall season, Mary’s times begin to fall off slightly. When asked about her performance, she states that she has been experiencing pain in both her shins, particularly the one on the right, for two weeks. Her coach, because of her concern, asks Mary to see her family doctor, since Mary’s school does not have an athletic trainer or team physician. Mary’s doctor, who is not trained in sports medicine, simply tells Mary that she has shin splints and that she should rest. Mary does not accept this, because everyone is counting on her to win for her school. She continues to run against his advice. In the next race, Mary finishes dead last. The pain has become quite unbearable. Mary is finally referred to a sports medicine physician, who discovers several relevant facts. Mary has not been eating well and has in fact been forcing herself to vomit for a number of days prior to each race. Also, Mary has not experienced her first menses, and her secondary sexual characteristics are somewhat immature. x-rays of Mary’s right leg reveal a stress fracture that is quite severe. Mary is referred to several people, including an orthopedic surgeon who places her in a cast, a nutritionist and a psychologist who evaluate and treat her eating disorder, and a gynecologist who proceeds with a workup for her late development. After several months of treatments from all three doctors, Mary begins retraining on a bicycle under the direction of an athletic trainer and a physical therapist. She moves on to compete in the spring season of track and field and becomes a national champion. Without the aid of the sports medicine team, Mary might have continued to have difficulty and might not have been evaluated properly until it was too late. This is a quite common scenario among adolescent athletes. The pressures placed upon them by friends, coaches, and parents can become detrimental to their emotional and physical well-being.


Henry is a fifty-five-year-old businessman who spends five days a week playing tennis at the local health club to stay in shape. After buying a new racket, he begins to experience pain in his right elbow. He is seen by an orthopedic surgeon in town who specializes in sports medicine. After speaking with Henry and examining his elbow, the doctor recommends anti-inflammatory medication, a special forearm strap, and use of the old racket. Henry’s condition, which is called tennis elbow, or lateral epicondylitis, is quite common. After several weeks of the initial treatment, Henry does not feel any better. His doctor, therefore, injects him with a medicine to ease the pain and calm the inflammation. Henry is instructed to rest his arm for a week prior to starting tennis again. Henry follows the doctor’s instructions carefully. He begins to play tennis again and feels fine for about a month, after which he begins to experience the same discomfort. This time, the doctor recommends surgery for Henry’s elbow. Three months after the surgery, Henry is free of pain.


These examples have demonstrated how sports medicine can be beneficial to athletes. Each scenario differs in type of athlete, location, diagnosis, and treatment.




Perspective and Prospects

Sports medicine is assuming a significant role in the medical profession today. Sports medicine was first recognized in the days of the early Olympics. It was not until the final decades of the twentieth century, however, that it emerged into a field of its own. Sports medicine training programs have been developing at an exponential rate. Interest in sports medicine can be pursued in various ways. Most sports medicine physicians undergo a one-year fellowship after either a five-year orthopedic residency training program or a three-year family medicine residency training program. Athletic trainers must pass a national examination for certification. Most have master’s degrees, and all have some form of bachelor’s degree. Their expertise is in the prevention, treatment, and rehabilitation of athletic injuries. These are the primary caregivers of the sports medicine world. Certified athletic trainers are being hired at all major universities, many high schools, and many health clubs across the country. Various types of sports medicine centers are continually being developed. These centers offer a wide range of services to both professional and amateur athletes. As more and more people begin to exercise, the need for sports medicine professionals will increase.


Athletes’ needs and goals are different from those of most other people. Although the injuries that they experience are not unique to sports, the rapidity with which they recover is of utmost importance. This identifies them as a distinct group of people with special demands for medical care. It is because of this and because of the growing number of people who exercise on a daily basis that sports medicine has evolved into a viable medical field. Sports medicine will continue to grow and will play an important role in preventing many of the injuries that afflict people in the United States.




Bibliography


Andrews, James R., and Don Yaeger. Any Given Monday: Sports Injuries and How to Prevent Them. New York: Scribner, 2013. Print.



Blumenstein, Boris, Michael Bar-Eli, and Gershon Tenenbaum, eds. Brain and Body in Sport and Exercise: Biofeedback Applications in Performance Enhancement. New York: Wiley, 2002. Print.



Carter, Neil. Medicine, Sport, and the Body: A Historical Perspective. New York: Bloomsbury, 2012. Print.



Delforge, Gary. Musculoskeletal Trauma: Implications for Sport Injury Management. Champaign: Human Kinetics, 2002. Print.



Landry, Gregory L., and David T. Bernhardt. Essentials of Primary Care Sports Medicine. Champaign: Human Kinetics, 2003. Print.



McArdle, William, Frank I. Katch, and Victor L. Katch. Exercise Physiology: Energy, Nutrition, and Human Performance. 8th ed. Boston: Lippincott, 2014. Print.



Plowman, Sharon A., and Denise L. Smith. Exercise Physiology for Health Fitness and Performance. 4th ed. Philadelphia: Lippincott, 2013. Print.



Scuderi, Giles R., and Peter D. McCann, eds. Sports Medicine: A Comprehensive Approach. 2nd ed. Philadelphia: Mosby/Elsevier, 2005. Print.



Small, Eric, et al. Kids and Sports: Everything You and Your Child Need to Know about Sports, Physical Activity, and Good Health. New York: Newmarket, 2002. Print.



Ward, Keith. Routledge Handbook of Sports Therapy, Injury Assessment, and Rehabilitation. New York: Routledge, 2015. Print.

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