Wednesday, October 24, 2012

For rats, is there a chemical or a product that will disable consolidation in the amygdala? I don't want one that will block reconsolidation...

You may find the following article helpful. I'm not able to access the full text, but you may be able to if your institution has access. From the abstract, it seems highly relevant to your question. 


Amygdala BDNF signaling is required for consolidation but not encoding of extinction. Nature Neuroscience 9, 870-872 (2006).


I believe you are searching for an antagonist of BDNF. However, BDNF works through the TrkB receptor. This abstract states that there are no selective antagonists for BDNF available, so they used a different approach.


You may find it useful to search more recent publications which have cited this paper. You can do so by first finding the article using Google Scholar. A small blue link 'Cited by' followed by the number of articles citing the article in question will appear below the listing on the left. 

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