Bromelain
Effect: Possible Helpful Interaction
According to two studies, the supplement bromelain (from pineapple stems) may
increase the absorption of amoxicillin. This effect might help the
antibiotic work better.
Vitamin K
Effect: Possible Nutritional Depletion
There are concerns that antibiotic treatment might reduce levels of
vitamin
K in the body. However, this effect seems to be slight and
only significant in persons who are already considerably deficient in vitamin
K.
Bibliography
Cohen, H., et al. “The Development of Hypoprothrombinaemia Following Antibiotic Therapy in Malnourished Patients with Low Serum Vitamin K1 Levels.” British Journal of Haematology 68 (1988): 63-66.
Conly, J., and K. Stein. “Reduction of Vitamin K2 Concentrations in Human Liver Associated with the Use of Broad Spectrum Antimicrobials.” Clinical and Investigative Medicine 17 (1994): 531-539.
Goss, T. F., et al. “Prospective Evaluation of Risk Factors for Antibiotic-Associated Bleeding in Critically Ill Patients.” Pharmacotherapy 12 (1992): 283-291.
Shearer, M. J., et al. “Mechanism of Cephalosporin-Induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status.” Journal of Clinical Pharmacology 28 (1988): 88-95.
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