Saturday, July 16, 2011

What is amoxicillin? How does it interact with other drugs?



Bromelain


Effect: Possible Helpful Interaction


According to two studies, the supplement bromelain (from pineapple stems) may
increase the absorption of amoxicillin. This effect might help the
antibiotic work better.




Vitamin K


Effect: Possible Nutritional Depletion


There are concerns that antibiotic treatment might reduce levels of
vitamin
K in the body. However, this effect seems to be slight and
only significant in persons who are already considerably deficient in vitamin
K.







Bibliography


Cohen, H., et al. “The Development of Hypoprothrombinaemia Following Antibiotic Therapy in Malnourished Patients with Low Serum Vitamin K1 Levels.” British Journal of Haematology 68 (1988): 63-66.



Conly, J., and K. Stein. “Reduction of Vitamin K2 Concentrations in Human Liver Associated with the Use of Broad Spectrum Antimicrobials.” Clinical and Investigative Medicine 17 (1994): 531-539.



Goss, T. F., et al. “Prospective Evaluation of Risk Factors for Antibiotic-Associated Bleeding in Critically Ill Patients.” Pharmacotherapy 12 (1992): 283-291.



Shearer, M. J., et al. “Mechanism of Cephalosporin-Induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status.” Journal of Clinical Pharmacology 28 (1988): 88-95.






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