What is clonidine? How does it interact with other drugs?

Coenzyme Q10 (CoQ10)

Effect: Supplementation Possibly Helpful

There is some evidence that clonidine might impair the body’s ability to
manufacture the substance CoQ10. However, it has not yet been shown
that CoQ10 supplements offer any particular benefit
to those taking this medication.

Yohimbe

Effect: Probable Dangerous Interaction

Persons taking clonidine should not take yohimbe.

Coleus forskohlii

Effect: Theoretical Interaction

The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with clonidine.

Bibliography

Brinker, F. Herb Contraindications and Drug Interactions. 2d ed. Sandy, Oreg.: Eclectic Medical, 1998.

Kishi, H., et al. “Bioenergetics in Clinical Medicine IIII: Inhibition of Coenzyme Q10-Enzymes by Clinically Used Anti-hypertensive Drugs.” Research Communications in Chemical Pathology and Pharmacology 12, no. 3 (1975): 533-540.